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Clinical research on pyridoxine in relation to neurological effects (see Table 2 for individual/anecdotal proof) Duration Dosage Authors Subjects Number of Findings Conclusions (mg/day) treatment No adjustments in distal Patients with motor Duration too Del Tredici et al carpal tunnel 24 150 or 300 four months latency or quick to assess (1985) syndrome self-assesneurological results sment questionnairethe situation could also be due to pyridoxine de Ellis et al Patients with No antagonistic ciency; typical therapy (1979) (and carpal tunnel 35 one hundred-300 as much as 12 neurologischedule of 12 weeks research cited); syndrome weeks cal results (Ellis, 1987) is of too short Ellis (1987) reported duration to access neurological results Patients with No assessDuration too Kerr (1977) premenstrual 70 forty-100 2 months ment of side quick to evaluate syndrome effects neurological results No neurological comSmall group measurement but plications in very prolonged period; Patients with 22 patients inuence of the or nerve Mitwalli et al hyperoxaluria 22 250-500 1-6 years conduction illness on (1984) (kidney abnormapyridoxine dealing with, stones) necessities and lities in 7 sufferers neurological response aren’t identified studied intimately Small group measurement but very No abnorextended duration; the malities of absence of results at Patients with motor or doses equal to 10-ninety Mpofu et al homocystei17 200-500 10-24 years sensory mg/kg/day means that (1991) nuria nerve these sufferers may present conduction decreased responsiveness velocities to the neuronal adverse effects of pyridoxine Pauling (1984) Undened >5000 200 not given No particulars No particulars available; cites Hawkins sufferers can’t be assessed No assesResults from a survey Pullon et al Women 410 not described not described sments of of 1826 women; no (1989) possible data on tolerability neuropathy and side effects No effects Small variety of topics and really restricted Tolis et al Women 9 200 or 400 2 months on progress duration of treatment; (1977) hormone or no evaluation of prolactin neurological results No difference in Women with unwanted effects Duration too Williams et al premenstrual 204 (out one hundred 3 months between quick to access (1985) syndrome of 434) therapies neurological results and placebo groups Data evaluation for A systematic evaluation of published and Women with reviews of unpublished Wyatt et al premenstrual 526 (out 50-600 up to 4 unwanted side effects; randomised (1999) syndrome of 910) months 1 reported placebo controlled case of trials; all research of neurological insufficient period side effects 37 europa. 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